Here's an interesting change...in the VERY end of the game. It seems that NOA was not confident in making a "Mother 3". So instead they give us a sappy "The End..?". Also, you know how in you input your name twice during the game? Well, in Mother 2, you input your name in English, and the second time in Japanese. Why?
The Japanese name shows up when you're praying, and the English name appears in the credits.
Thanks to Tomato for providing this Mother 2 information! Visit his Mother 2 to EarthBound and Back Again translation site for more Mother 2 to EB comparisons!